Blar i forfatter "Bhavsar, Swapnil Parashram"

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    • Drug resistance and the functional role of microRNAs in neuroblastoma 

      Bhavsar, Swapnil Parashram (Doctoral thesis; Doktorgradsavhandling, 2019-06-13)
      Neuroblastoma is the most common solid tumor in infants. Most of the children diagnosed above one year of age, shows metastatic disease and poor prognosis. Chemotherapy is one of the principle mode of treatment. However, resistance to drug represent a major clinical obstacle for the effective treatment of cancer. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression, ...

    • Hsa-miR-376c-3p targets cyclin D1 and induces G1-cell cycle arrest in neuroblastoma cells 

      Bhavsar, Swapnil Parashram; Løkke, Cecilie; Flægstad, Trond; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-11)
      High‑risk neuroblastoma is the most aggressive form of cancer in children. The estimated survival of children with high‑risk neuroblastoma is 40‑50% compared with low and intermediate risk neuroblastoma, which is >98 and 90‑95%, respectively. In addition, patients with high‑risk neuroblastoma often experience relapse following intensive treatments with standard chemotherapeutic drugs. Therefore ...